Abstract
Shewanella algae is an emerging marine zoonotic pathogen and accounts for considerable mortality and morbidity in compromised hosts. However, there is scarce literature related to the understanding of the genetic background of virulence determinants in S. algae. In this study, we aim to determine the occurrence of common virulence genes in S. algae using whole-genome sequence and comparative genomic analysis. Comparative genomics reveals putative-virulence genes related to bile resistance, chemotaxis, hemolysis, and motility. We detected the existence of hlyA, hlyD, and hlyIII involved in hemolysis. We also found chemotaxis gene cluster cheYZA operon and cheW gene. The results provide insights into the genetic basis underlying pathogenicity in S. algae.
Highlights
Shewanella algae is an emerging marine zoonotic pathogen. e organism was first classified in 1990 by Simidu et al [1], emended by Nozue et al [2], and described as a Gramnegative, motile bacillus, with hydrogen sulfide production, exhibiting hemolysis on sheep blood agar
S. algae is found in marine environments throughout the world and has been linked with both human and marine animal infections [3, 4]
Marine ecosystem consists of a large variety of organisms that impact human health [10]. e advance of sequencing technology allows the identification of determinants in pathogenic microorganisms and has become an important approach to study the fundamental mechanisms of pathogenesis [11, 12]
Summary
Shewanella algae is an emerging marine zoonotic pathogen. e organism was first classified in 1990 by Simidu et al [1], emended by Nozue et al [2], and described as a Gramnegative, motile bacillus, with hydrogen sulfide production, exhibiting hemolysis on sheep blood agar. Shewanella algae is an emerging marine zoonotic pathogen. S. algae is found in marine environments throughout the world and has been linked with both human and marine animal infections [3, 4]. There are at least three other Shewanella species found in clinical specimens and S. algae accounts for the majority of isolates from humans [5, 6]. Marine ecosystem consists of a large variety of organisms that impact human health [10]. E advance of sequencing technology allows the identification of determinants in pathogenic microorganisms and has become an important approach to study the fundamental mechanisms of pathogenesis [11, 12]. There have been attempts to use wholegenome sequencing in the study of marine pathogens [14]
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Schedule a callMore From: The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
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