Abstract
Leptospira interrogans serovar Canicola is one of the most important pathogenic serovars for the maintenance of urban leptospirosis. Even though it is considered highly adapted to dogs, serovar Canicola infection has already been described in other animals and even a few human cases. Here, we present the genomic characterisation of two Brazilian L. interrogans serovar Canicola strains isolated from slaughtered sows (L0-3 and L0-4) and their comparison with human strain Fiocruz LV133. It was observed that the porcine serovar Canicola strains present the genetic machinery to cause human infection and, therefore, represent a higher risk to public health. Both human and porcine serovar Canicola isolates also presented sequences with high identity to the Chinese serovar Canicola published plasmids pGui1 and pGui2. The plasmids identification in the Brazilian and Chinese serovar Canicola strains suggest that extra-chromosomal elements are one more feature of this serovar that was previously unnoticed.
Highlights
Leptospirosis is a re-emerging zoonosis in both developed and developing countries (Dupouey et al 2014)
The L. interrogans serovar Canicola is one of the most important pathogenic leptospires and, it is considered highly adapted to dogs (Schuller et al 2015), serovar Canicola infection has already been described in swine and a few human cases (Lecour et al 1989, Bolin 1994, Trevejo et al 1998, Zhu et al 2014)
We present the genomic characterisation of two Brazilian L. interrogans serovar Canicola strains (L0-3 and L0-4) isolated from slaughtered sows and their comparison with human strain Fiocruz LV133 (GenBank accession number AKWU2000000)
Summary
Leptospirosis is a re-emerging zoonosis in both developed and developing countries (Dupouey et al 2014). We present the genomic characterisation of two Brazilian L. interrogans serovar Canicola strains (L0-3 and L0-4) isolated from slaughtered sows and their comparison with human strain Fiocruz LV133 (GenBank accession number AKWU2000000). The obtained contigs were ordered according to L. interrogans serovar Copenhageni strain Fiocruz L1130 reference genome (GenBank accession numbers NC_005823 and NC_005824).
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