Abstract
Eastern cotton rats, Sigmodon hispidus hispidus, and Texas cotton rats, Sigmodon hispidus texianus, were infected with a strain of filarial worms, Litomosoides carinii, derived from eastern cotton rats. During the first 23 days worms of a primary infection developed equally well in either strain of rats. Worms of superimposed infections were retarded in growth and development to a statistically significant degree in either strain of cotton rats harboring worms from a single previous infection.
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