Abstract
The aim of the present study was to characterize comparative excretion of pure vitexin-2-O-rhamnoside (VR) in mice following oral and intravenous administration at dose of 30 mg/kg, therefore, a sensitive and specific high-performance liquid chromatography (HPLC) method using vitexin-4-O-glucoside as internal standard developed and validated for quantitative analysis of VR. The results of elimination of VR in urinary and fecal excretion following oral and intravenous dosing indicated that VR was mainly excreted as prototype for both routes of administration, and biliary and renal excretions are two major ways for the elimination of VR. Key words: Excretion, high-performance liquid chromatography (HPLC), Vitexin-2-O-rhamnoside.
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