Abstract
It is of interest to evaluate a single dose of three different analgesics compared to placebo in patients with symptomatic irreversible pulpitis. 120 patients were enrolled with severe pain in this prospective clinical trial. Patients were randomly divided into four groups after shaping and cleaning of root canals. This includes placebo, piroxicam 20mg, acetaminophen 325mg with aceclofenac sodium 100mg and acetaminophen 650mg. Participants were given a questionnaire to note the pain scores at various time intervals (6 hrs, 12 hrs, and 24 hrs) along with the respective tablets in a concealed manner. Data thus collected was analyzed for statistical significance. The severity of pain decreased in all the three interventional groups compared to the control group (p <0.01) at 6 hours. Zerodol-P and dolonex showed better pain reduction in comparison to the placebo and dolo 650 group (p <0.05) at 12 and 24 hours. Data shows that both zerodol-P and dolonex groups had similar effects at all time intervals. Thus, a single dose of analgesic such as Zerodol-P and Dolonex following shaping and cleaning of root canals relieved pain at all time intervals of the treatment. However, Dolo 650 performed better during the initial 6hrs after completion of the shaping and cleaning of root canals compared to the placebo.
Highlights
Pulpitis can be defined as the inflammation of the pulp mainly due to cariogenic reasons and less often due to trauma and restorative treatment
At 6 hours interval, all the interventional groups resulted in significant pain reduction when compared to the placebo group (p
No statistical significant difference was seen amongst group I and group IV at 12 and 24 hours (p>0.05) (Figure 2: Pain Reduction at all time intervals)
Summary
Pulpitis can be defined as the inflammation of the pulp mainly due to cariogenic reasons and less often due to trauma and restorative treatment. The major reasons for the pain are due to the release of inflammatory mediators, which activates the nociceptors surrounding the tooth [2]. Ng et al showed that the patient experiences pain after completing the endodontic treatment is ISSN 0973-2063 (online) 0973-8894 (print). The main action of Non-steroidal anti-inflammatory drugs (NSAID) consists of decreasing the inflammation thereby down regulating the activity of cyclooxygenase (COX) enzymes, which exist in two iso-forms namely COX-1 and COX -2. Aceclofenac sodium is a phenylacetic acid derivative and a potent analgesic and anti-inflammatory agent. It inhibits the action of COX enzyme, which is involved in the synthesis of prostaglandins [5]. The aim of this study is to evaluate various analgesics in irreversible pulpitis to eliminate pain
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