Comparative Evaluation of the Plaque and Gingivitis Reducing Efficacy of Chlorhexidine Diundecylinate (Salibact) and Triclosan Based Dentifrice: A Double Blind Randomized Controlled Trial

Abstract

Background: Microbial complexity of biofilm indicate that streptocouss mutans and candida species lives in symbiotic relationship. The combination of antiplaque agent with antifungal agent can significantly influence the dental plaque. There is a search for effective antimicrobial agent in dentifrice formulation. chlorhexidine diundecylinate((CHUA) is novel antimicrobial agent introduced by salicylates and chemicals pvt ltd, has shown extended antimicrobial properties and are comparable to triclosan Objectives: To evaluate and compare the plaque and gingivitis reducing efficacy of chlorhexidine Diundecylinate (salibact) and triclosan based dentifrice Material and methods: A double blind randomized controlled trial was conducted among 86 subjects who are randomly divided into two groups. Experimental group received dentifrice containing chlorhexidine Diundecylinate with antidiscoloration system (salibact 0.1%+ ADS) and control group received 0.3% triclosan containing dentifrice.Plaque and gingival index scores were compared between baseline and six weeks. Results: There is a significant difference between mean plaque index scores between salibact and triclosan containing dentifrice p(0.032)(0.015)<0.05 respectively. Mean plaque and gingivitis reduction was found to be better for salibact compared to triclosan Conclusion: The study results provide some evidence that CHUA (Salibact) has definite role in plaque reduction and has better efficacy compared to triclosan. The new ingredient chlorhexidine diundecylenate seems to be a better choice as an efficient antimicrobial agent for the oral care dentifrice formulations.