Abstract
To test the hypothesis that the tropism of tetracyclines for bone tissue is largely dependent on their affinity for calcium, a comparative study of the effects of 4 tetracyclines on the skeletal development of the chick embryo was performed. These were tetracycline, oxytetracycline, methacycline and doxycycline, possessing different degrees of affinity for divalent ions. Tetracycline, which has the highest degree of affinity for calcium, induced an appreciable reduction in skeletal development when injected into the yolk sac on day 4 of incubation. This reduction was less significant with equimolecular doses of oxytetracycline and methacycline, and even less with doxycycline, which among these 4 antibiotics has the lowest degree of affinity for calcium.
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