Comparative Evaluation of the Efficacy of Shatavari Ghanavati & Bramhi Ghanvati in Jarajanya smritibramsha (Senile Dementia)

Abstract

Background: Memory is the important physiological process which is required to live normal life. Good and bad memories helps living being in stay protected from harms. In old age, these aspect of normal human physiology get deteriorated. This occurs due to increase in Vata dosha. As age progresses there is increase in vata causing diminished memory. There are various drugs which are prescribed by doctors for age associated memory disorder. Bramhi, Shankhpushpi, Mandukparni are the well-known drugs as memory booster. But in Bhavprakash Samhita and Kashyap samhita, Shatavari is described for its nootropic property.
 Aim: Comparative evaluation of Shatavari ghanavati and Bramhi ghanavati in Jarajanya smritibhramsha (Senile Dementia).
 Objectives:
 
 To confirm the most safest and effective dose of Shatavari in senile dementia by reverse pharmacology approach.
 To evaluate the efficacy of Shatavari ghanavati on cognitive function in Senile dementia.
 To evaluate the efficacy of Bramhi ghanavati on cognitive function in Senile dementia.
 To evaluate the efficacy of Shatavari ghanavati as an Antioxidant.
 To evaluate the efficacy of Bramhi ghanavati as an Antioxidant.
 To evaluate the comparative efficacy of Bramhi ghanavati and Shatavari ghanavati on cognitive function in Senile dementia.
 
 Methodology: In this study there will be two parts, to define safest and most effective dose in Senile dementia by reverse pharmacology and main study. In reverse pharmacology, 10 patients will be selected in each group. After this, 30 patients will be selected in control arm of bhramhi ghanavati and 30 in Shatavari ghanavati, experimental group. Patients will be assessed with MMSE scale.
 Results: Shatavari is well known rasayan drug. Along with this, its has medhya (nootropic properties). It will work on memory as it acts as an antioxidant. The property will be studied by assessing SOD and MDA.
 Conclusion: Conclusion will be drawn according to results.