Abstract
HA (Hyaluronic acid) filler, the most commonly used dermal filler, causes several side effects. HA-PN (Hyaluronic acid-Polynucleotide), a new composite filler, has excellent biocompatibility and induces tissue regeneration. In this study, we compare the efficacies and safety profiles of these fillers. The characteristics of HA and HA–PN fillers were compared using scanning electron microscopy and rheometry. No morphological difference was noted between the fillers. However, the latter had higher viscosity and elasticity values. The HA-PN filler induced higher cell migration than the HA filler in a wound healing assay. It was also found to stimulate better collagen synthesis in human and mouse fibroblasts. The HA and HA–PN fillers were injected into SKH1 hairless mice to determine changes in their volume for up to 24 weeks. Increased cell migration and collagen synthesis were observed in mice injected with the HA–PN complex filler. Although the safety and durability of the HA and HA–PN fillers were similar, the latter induced a lower transient receptor potential vanilloid 4 expression and caused less stimulation upon injection. In conclusion, HA–PN complex fillers can stimulate fibroblast growth and facilitate volume growth and skin regeneration.
Highlights
Synthetic facial fillers are composed of a biosynthetic polymer in combination with different injectable carriers, including hydrogels, beads, and liquids[4]
It has been reported that nucleotides promote the growth of human corneal fibroblasts and increase their remnants in ultraviolet B-damaged skin fibroblasts[17]
This study aimed to demonstrate the commercial feasibility of the hyaluronic acid (HA)–PN complex filler by comparing the efficacies and safety profiles of HA and HA–PN complex fillers in vitro and in vivo
Summary
Synthetic facial fillers are composed of a biosynthetic polymer in combination with different injectable carriers, including hydrogels, beads, and liquids[4]. Various dermal fillers have been developed to overcome the adverse effects accompanying the use of HA fillers[6,11,12,13,14]. A new filler product was synthesised using a purified polynucleotide (PN) extracted from salmon and other fish germ cells. This product is currently in use in Europe[15]. In vitro studies have demonstrated the therapeutic efficacy of polynucleotides in patients who received treatment for skin ectopia and have shown that polynucleotides promote rapid corneal epithelialisation after photorefractive keratectomy[18,19]. Which has the advantages of both tissue regeneration and durability This filler overcomes the disadvantages of its individual components. This study aimed to demonstrate the commercial feasibility of the HA–PN complex filler by comparing the efficacies and safety profiles of HA and HA–PN complex fillers in vitro and in vivo
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