Abstract
The undesirable bioactivity on the surface of titanium such as lack of osteoinduction is a major contributing factor for the failure of orthopedic implants, while calcium phosphate and calcium silicate coatings are two effective strategies to improve the osteoinduction of the implants. In addition, the incorporation of strontium (Sr) could further enhance the bioactivity of the coatings. However, it remains unknown whether Sr-incorporated calcium phosphate (P-Sr) or Sr-incorporated calcium silicate (Si-Sr) has a better performance. In this study, the P-Sr and Si-Sr coatings were fabricated on titanium alloy (Ti-6Al-4V, TC4) respectively by micro arc oxidation (MAO) and the biological properties of the two coatings were compared. Both coatings not only can enhance the corrosion resistance and hydrophilic state of TC4 substrates but also promote the bioactivity and osteogenic differentiation ability. Compared with Si-Sr coating, the P-Sr coating has better biocompatibility, especially its cell adhesion at 1 h and cell proliferation after 4 days. In addition, P-Sr coating showed better performance on the secretion of ALP and the extracellular matrix mineralization of BMSCs compared to silicate coating. These results provide evidence of comparative evaluation for the selection of P-Sr coating and Si-Sr coating, and P-Sr coating is a better strategy for orthopedic application in the future.
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