Abstract
ObjectiveThis study aims to relate aspartate aminotransferase (AST) in saliva and periodontal status in patients with gingivitis and periodontitis.MethodsForty-five patients have undergone a periodontal detailed examination as well as indexes sorted and classified into three gingival-based groups: healthy, gingivitis and periodontitis. Fifteen (15) patients were assigned for each group. Ten milliliter of stimulated saliva from a patient was collected after rinsing the mouth with 15 mL of water in a sterile tube. Biochemical analysis was conducted using the study GOT (ASAT) IFCC mod. liquiUV kit from HUMAN. Kinetic method for the determination of GOT (ASAT) activity and TC 84 Teco diagnostics chemistry analyzer.ResultAcquired results indicated statically significant increases of AST level in saliva from patients with periodontitis and gingivitis (p < 0.01) in relation to the control group.ConclusionThese results revealed that salivary AST level is higher in patients that have periodontal destruction, pocket depth and bleeding in probing. This clinically indicated that salivary biomarkers can be used as a diagnostic tool for the evaluation of periodontal health status.
Highlights
Periodontitis is a common inflammatory disease that has many causes
The objective is to estimate the levels of enzymes AST in the saliva of healthy subjects, gingivitis, and chronic periodontitis patients, to assess and compare the activity of the enzyme between healthy subjects, gingivitis and chronic periodontitis groups and to correlate the level of an estimated enzyme with that of clinical parameters in healthy subjects, gingivitis patients and patients with chronic periodontitis
Group II Chronic gingivitis patients (Study Group): this group was composed of contributors with probing depth equal to or less than 3mm, at least 20 natural teeth and absence of attachment loss and bleeding on probing with more than 20% sites
Summary
Periodontitis is a common inflammatory disease that has many causes. Periodontitis is mainly known as an inflammatory disease that affects the periodontium [1]. Periodontitis is caused mainly by microorganisms that adhere to teeth and grow. Periodontitis is diagnosed by probing the gingival sulcus and using a radiograph. For assessment and determination of the current status of the disease, these procedures are not good. They are excellent to assess and determine the disease history [2]
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