Comparative evaluation of platelet rich fibrin matrix (PRFM) membrane and collagen membrane with demineralized freeze-dried bone allograft (DFDBA) in the treatment of mandibular class II furcation defects: A randomized controlled trial

Abstract

Aim- The aim of the study was to compare the effectiveness of platelet rich fibrin matrix (PRFM) membrane with collagen membrane (Colo Gide) in combination with demineralized freeze-dried bone allograft (DFDBA) in the treatment of mandibular Class II furcation defects. Methods- This randomized, parallel designed, controlled, clinical investigation was conducted in 24 subjects (15 male and 9 female) having Class II furcation defects either buccally or lingually. The test group was treated with DFDBA and PRFM membrane while the control group was treated with DFDBA and collagen membrane. The clinical measurements such as plaque index (PI), papillary bleeding index (PBI), pocket probing depth (PPD), relative attachment level (R-CAL) and relative gingival marginal level (R-GML) were measured at baseline and six months. Radiographic parameters, such as vertical defect depth (VDD), horizontal defect depth (HDD) and defect width (DW) were measured using cone beam computed tomography taken at baseline, three and six months. Student’s paired t-test was utilized to analyse data from the day of surgery to six months. A comparison of both groups at baseline and six months was achieved by student’s unpaired t-test. Result-10 sites in test group (83.33%) showed the advancement from class II to class I compared to eight sites in control (66.66%). Remaining defects in test group n=2 (16.66%) and control group n=4 (33.33%) showed marked reduction in horizontal defect depth compared to baseline. No complete closure of the defect was seen in either group. Conclusion- When treating class II furcation defects, the use of PRFM membrane combined with DFDBA seems to be advantages with regards to collagen membrane. The presented set up seems feasible with regards to randomization, acceptance, retention and achievement of satisfactory outcomes.