“COMPARATIVE EVALUATION OF PALONOSETRON & PALONOSETRON WITH OLANZAPINE FOR PREVENTION OF POST OPERATIVE NAUSEA VOMITING IN PATIENTS UNDERGOING GYNAECOLOGICAL SURGERIES”

Abstract

Background: The second most frequent post-operative complaint after pain is post-operative nausea and vomiting (PONV). There are numerous factors that can cause PONV, including the length of the procedure, the type of medicines used during anaesthesia, the anaesthetic technique, age, sex, and smoking habits. Depending on the type of operation and related risk factors, the incidence of PONV has been reported to range from 30 to 80%. Without any antiemetic medication, there is a 60% to 80% chance of PONV following general anaesthesia. Prevention of PONV can improve both the physical & phycological recovery of patient post-surgery. Palonosetron is a selective 5-hydroxytryptamine type3(5-HT3) receptor antagonists. It has a greater receptor binding afnity and a much longer half-life, conferring a prolonged duration of action, exceeding 40 hours, compared with other 5-HT3 receptor antagonists.[1] Olanzapine is an atypical antipsychotic agent of the thienobenzodiazepine class, blocks multiple neurotransmitter receptors, including dopaminergic (D1, D2, D3, D4), serotonergic (5-HT2a, 5-HT2c, 5-HT3, 5-HT6), adrenergic (alpha1), histaminic (H1), and muscarinic (m1, m2, m3, m4) receptors.[2] Aim: To compare the effect of palonosetron and palonosetron plus olanzapine for prevention of post operative nausea vomiting in patients undergoing gynecological surgeries