Comparative evaluation of Optical Coherence Tomography (OCT) with Pattern Reversal Visual Evoked Potential (PRVEP) in early primary open angle glaucoma

Abstract

Present study is to correlate the average retinal nerve fiber layer (RNFL) thickness and the visual function evaluated by electrophysiologic retinal and cortical responses assessed in primary open-angle glaucoma (POAG) eyes by a Case-control study. One hundred and sixty-one control and glaucoma patients (mean age, 55.18±5.19 years for study group and 54.45±4.81 years for control group) were selected in the study. Average Retinal Nerve fiber layer thickness was measured by optical coherence tomography. Retinal and visual pathway function was assessed by simultaneously recording pattern reversal visual evoked potentials (PRVEPs) Linear regression analyses were adopted to establish the correlation between average RNFL thickness and PRVEP parameters. Average Retinal Nerve fiber layer thickness were taken. PRVEP, P100 latency and N75-P100 amplitude were also measured. In POAG eyes, we found a significant (P< 0.01) reduction in average RNFL thickness with respect to the values observed in control eyes. PRVEP parameters showed a significant (p< 0.01) delay in p100 latency and reduced N75 p100 amplitude. Positive correlations between average RNFL values and PRVEP parameters were found. There is a positive correlation between PRVEP changes and average RNFL thickness, in POAG patients.