Abstract
Conventional Periodontal therapy such as scaling and root planing and open flap debridement aims to halt the inflammation process and promotes repair of disease-related defects. Current regenerative procedures offers a limited potential toward attaining a complete periodontal restoration and none is considered a gold standard in the treatment of intrabony defects. This study was done to compare the efficiency of Titanium-Platelet Rich Fibrin and Leukocyte-Platelet Rich Fibrin as adjuncts to Open Flap Debridement therapy to treat intra-bony periodontal defects. A search was conducted through PubMed and various other databases such as Cochrane, Google Scholar and EBSCO Host , under the key words, OFD , T-PRF,L-PRF, Clinical Outcomes, Comparison and Randomised Contolled Trials. Six relevant articles were selected for analysis. Compared to non-platelet concentrates, L-PRFproves to be the better adjunct to open flap debridement therapy. When compared to T-PRF, however, L-PRF has comparatively inferior properties of bone defect resolution and fill.We can conclude that T-PRF has better properties, greater bone defect fill and defect resolution as compared to L-PRF.
Highlights
Periodontitis is characterized by microbiallyassociated, host-mediated inflammation that results in loss of periodontal attachment [1]
In both the studies conducted by Pradeep A et al, the first in 2009, and the in 2012, L-Platelet rich fibrin (PRF) was compared to Peptide Enhanced Bone graft and Platelet Rich Plasma (PRP)
In the study conducted by Mathur et al in 2015, LPRF was compared with Autologous Bone Graft (ABG) and it was proven that the L-PRF group showed greater bone defect resolution compared to ABG
Summary
Periodontitis is characterized by microbiallyassociated, host-mediated inflammation that results in loss of periodontal attachment [1]. Periodontal therapy aims to eliminate the inflammation process and promote bone and tissue healing. The purpose of said conventional therapeutic measures is to reduce pocket probing depth(PPD) and increase clinical attachment level(CAL).It cannot bring back the lost alveolar bone, which leads to periodontal regenerative therapy to repair the intra-bony defect. Periodontal regeneration is a complex multifactorial process involving biological events such as cell adhesion, proliferation, and differentiation in a sequential manner [2]. Among the techniques used to manage residual pockets after cause related therapy OFD (Open Flap Debridement) has been considered as standard and one of the earliest modality [3]. Several regenerative materials have been looked at for the management of intrabony defects such as; bone grafts/ bone substitute materials,guided tissue regeneration (GTR), growth factors and enamel matrix derivatives. The Choukroun’s Platelet-rich fibrin(PRF) is one such product that has proved its worth in terms of accelerated wound healing and regeneration [4,5]
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