Abstract
Three series of experiments were carried out and lethal doses of the new osteoplastic material 47.5 V were determined by the intraperitoneal and intragastric injection of the material to laboratory animals. A comparative evaluation with Bioactive glass BG-1D was also carried out. It was found that the LD50of 47,5B was 4274.51:4770.58 mg/kg for intragastric injection and 2358.31:2895.65 mg/kg for intraperitoneal injection to rats. In animals getting Bioactive glass BG-1D, these indicators changed slightly, amounting to 3439.04:3810.53 mg/kg and 1732.77:2730.93 mg/kg, respectively. Thus, according to the classification of substances according to the degree of toxicity, these materials can be attributed to practically non-toxic substances (according to the results of intraperitoneal injection of the material suspension to rats and mice) and low-toxic substances (according to the results of intragastric injection of the material suspension to rats)
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