Comparative Evaluation of Interleukin-17 in Gingival Crevicular Fluid of Patients with Aggressive Periodontitis and Healthy Gingival Sites

Abstract

Background: Aggressive periodontitis (AgP) is a severe form of periodontitis with rapid bone loss and clinical attachment loss. Many investigations aimed to understand its etiology and pathogenesis, however there is inadequate literature available regarding the level of interleukin-17 (IL-17) at sites of periodontal inflammation in AgP. Aim: The purpose of this study was to compare the levels of IL-17 in gingival crevicular fluid (GCF) of AgP patients with healthy sites of gingiva. Materials and Methods: GCF samples were obtained from individuals with clinically healthy gingiva (n = 15) and from AgP patients (n = 15). Clinical parameters including probing pocket depth (PPD), clinical attachment level (CAL), Papillary Bleeding Index (PBI), and Plaque index by Turkesy– Gilmore–Glickman Modification Of Quigley-Hein (PI) were measured. The level of IL 17 was measured by using enzyme linked immunosorbent assay (ELISA). Results: The level of GCF IL-17 was found to be statistically significantly increase in AgP (1.12 ± 0.29) as compared to healthy gingiva (0.64 ± 0.23). Clinical parameters such as modified PI, PPD, and PBI were significantly higher in AgP as compared to healthy clinical sites. Conclusion: The result of this study had shown that GCF IL-17 level was found to be elevated in AgP compared to healthy gingiva.