Comparative Evaluation of Healing Pattern After Surgical Excision of Oral Mucosal Lesions by Using Platelet-Rich Fibrin (PRF) Membrane and Collagen Membrane as Grafting Materials—A Randomized Clinical Trial

Abstract

To compare the healing potential of platelet-rich fibrin (PRF) and collagen membranes in oral mucosal healing. Thirty patients with oral premalignant lesions were randomly included in the study and divided in groups A and B. After excising the lesions under local anesthesia, patients in groups A and B underwent grafting with the PRF membrane and the collagen membrane, respectively. Patients were evaluated at postoperative days 7, 15, 30, and 60 for pain, healing, and complications, such as recurrence, fibrosis, scar hypertrophy, and loss of vestibular depth. In group A, 66.66% of patients reported substantially less pain postoperatively at 15-day follow-up than those in group B. At 30-day follow-up, 86.66% of patients in group A reported no pain versus 60% in group B. Pain scores were similar at 7- and 60-day follow-ups. Healing was accelerated in group A at 15- and 30-day follow-ups, but was the same on day 60. Complications, such as fibrosis, loss of vestibular depth, and scar hypertrophy, were seen in group B. Recurrence was seen in 1 patient in group A at 60-day follow-up. PRF proved superior to collagen membrane for grafting of oral mucosal surgical defects. However, further study with larger samples is required to prove its efficacy.