Abstract
The present study was carried out to find out the gastroprotective effects of the leaves extracts of Dypsis lutescens (H.Wendl.) and Caryota Urens (L.) in aspirin-induced gastric ulcer in rats. The ethanolic and aqueous extracts were prepared from the leaves of Dypsis lutescens and Caryota Urens and were used for this study. All procured animals were divided into seven groups. Each group contain n = 6, all groups except the normal control treated with aspirin 150 mg/kg oral. Group, I served as the normal control group which received normal saline, group II served as negative control and group III as standard group receiving 20 mg/kg omeprazole and 4th to 7th groups treated with leaves extracts of Dypsis lutescens and Caryota urens respectively. Treatment was given to group II to group VII rats in every 24 h for seven days. After 24 h fasting, on the 8th-day stomach contents were aspirated under anaesthetic condition to check free and total acidity. Stomachs were opened in all sacrificed animals along the greater curvature to estimate ulcer index, percentage protection and histopathology studies.
 The results of the present study revealed that the severity of aspirin-induced ulceration was significantly (P < 0.05) decreased in Dypsis lutescens extracts treated groups in comparison with the control and Caryota urens treated groups. It was observed that the free and total acidity significantly decreased in the aqueous extract of Dypsis lutescens treated group when compared with the negative control and Caryota urens treated groups.
Highlights
A peptic ulcer is a most common and genuine gastrointestinal problem which is caused due to the absence of equilibrium between the gastric secretions and the mucosal defensive components impacted by different aggressive and defensive factors such as acid-base balance and secretion, parietal cell activation, decrease in protective mucus secretion, decrease mucosal blood flow, the cellular recovery process, and endogenous protective factors like- prostaglandins and epidermal development factors [1,2]
The results of the present study revealed that the severity of aspirin-induced ulceration was significantly (P < 0.05) decreased in Dypsis lutescens extracts treated groups in comparison with the control and Caryota urens treated groups
Statistical analysis was performed by using analysis of variance (ANOVA) followed by Dunnett's test
Summary
A peptic ulcer is a most common and genuine gastrointestinal problem which is caused due to the absence of equilibrium between the gastric secretions and the mucosal defensive components impacted by different aggressive and defensive factors such as acid-base balance and secretion, parietal cell activation, decrease in protective mucus secretion, decrease mucosal blood flow, the cellular recovery process, and endogenous protective factors like- prostaglandins and epidermal development factors [1,2]. The mortality rate due to ulcers is approximately 5% per 100,000 cases. For this reason, a few pharmaceutical products have been utilized reliably for the treatment of gastric ulcers aiming to decrease morbidity and mortality rates [4]. In spite of the advancement in ulcer treatment from vagotomy to anticholinergic medications, H2receptor antagonists, acid neutralizers, proton pump inhibitors etc, in recent years the research has been reached out towards utilization of natural drugs, frequently named as complementary and alternative medicines (CAM‟s). Indigenous drugs possessing fewer side effects with maximum therapeutic efficacy is the area of interest for the present-day research which aims for a better and safer approach for the management of Peptic Ulcer Disease [5]
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