Comparative Evaluation of Formulations Designed using Chemically Modified Pectin and Eudragit for Sustained Release of Nateglinide

Abstract

The present work was proposed to chemically modified Pectin with its hydrophilicity reduced and potential for being an universal excipient. The Bulk densities of NTGT granules were found to be 0.3473 which indicate good packing capacity. Carr’s index of NTGT granules were found to be 5.88 which indicate excellent flow properties. Hausner ratio of NTGT granules were found to be 1.0621. Angle of repose of NTGT granules were excellent flow properties. The formulations MP1P2 after optimization to limit the release in the first 3 hrs could also be equally effective. Comparative evaluation of the designed formulations, the release of nateglinide from tablets coated with eudragit RL100 was progressively prolonged, as concentration of eudragit in the coating solution was increased about 63.91% at 12hr of NTGEUD3 batch. The formulated batches gives a clear indication that once daily formulations of nateglinide as oral hypoglycemics drug can be designed using this approach and subsequent release at a consistently uniform rate for sustained action has been achieved.