Abstract
Peripheral nerve injuries are one of those complex medical conditions for which a highly effective first-line treatment is currently missing. The use of natural compound as medicines to treat various disorders has a long history. Our previous research explored that crude Cannabis sativa L. accelerated the recovery of sensorimotor functions following nerve injury. The purpose of the current study was to investigate the effects of n-Hexane and ethyl acetate extracts of C.sativa L. leaves on the muscle function restoration in a mouse model after sciatic nerve injury. For this purpose, albino mice (n=18) were equally divided into control and two treatment groups. The control group was fed on a plain diet while treatment groups were given a diet having n-Hexane (treatment 1) and ethyl acetate (treatment 2) extracts of C.sativa L. (10mg/kg body weight), respectively. The hot plate test (M=15.61, SD=2.61, p=.001), grip strength (M=68.32, SD=3.22, p < .001), and sciatic functional index (SFI) (M=11.59, SD=6.54, p=.012) assessment indicated significant amelioration in treatment 1 as compared to treatment 2 group. Furthermore, muscle fiber cross-sectional area revealed a noticeable improvement (M=182,319, SD=35.80, p=.013) in treatment 1 while muscle mass ratio of Gastrocnemius (M=0.64, SD=0.08, p=.427) and Tibialis anterior (M=0.57, SD=0.04, p=.209) indicated nonsignificant change. A prominent increase in total antioxidant capacity (TAC) (M=3.76, SD=0.38, p < .001) and momentous decrease in total oxidant status (TOS) (M=11.28, SD=5.71, p < .001) along with blood glucose level indicated significant difference (M=105.5, SD=9.12, p < 0.001) in treatment 1 group. These results suggest that treatment 1 has the ability to speed up functional recovery after a peripheral nerve lesion. Further research is necessary, nevertheless, to better understand the extract's actual curative properties and the mechanisms that improve functional restoration.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
