Comparative Evaluation of Efficacy of Various Antibiotics in Treating Patients with Diarrhea: A Hospital Based Study

Abstract

Background: Diarrhea is a condition of altered intestinal water and electrolyte transport. The pathophysiologic mechanisms of diarrhea include osmotic, secretory, inflammatory, and altered motility. Hence; we planned the present study to assess and compare the efficacy of ofloxacin and combination of Norfloxacin and metronidazole (Nor Metrogyl) in treating patients with acute watery diarrhoea. Materials & Methods: The present study was conducted in the department of general medicine of RBM Hospital, Bharatpur, Rajasthan and included comparative evaluation of efficacy of ofloxacin and combination of Norfloxacin and metronidazole (Nor Metrogyl) in treating patients with acute watery diarrhoea. A total of 24 patients with chief complaint of acute watery diarrhea were included in the present study and were randomly divided into two study groups; group A and group B. group A included subjects who were treated with ofloxacin therapy while group B included subjects who were treated with Nor Metrogyl. All the results were analyzed by SPSS software. Results: A total of 24 patients were included in the present study and were randomly divided into two study groups with 12 patients in each group. We observed non-significant results while comparing the clinical success and biological success among patients of both the study groups. Conclusion: Both the treatment regimens are equally effective in treating diarrhea patients.