Abstract
Mammography is the best method for breast-cancer screening and is capable of reducing mortality rates. Studies that have assessed the clinical impact of mammography have been carried out using film mammography. Digital mammography has been proposed as a substitute for film mammography given the benefits inherent to digital technology. The aim of this study was to compare the performance of digital and film mammography. Systematic review and meta-analysis. The Medline, Scopus, Embase and Lilacs databases were searched looking for paired studies, cohorts and randomized controlled trials published up to 2009 that compared the performance of digital and film mammography, with regard to cancer detection, recall rates and tumor characteristics. The reference lists of included studies were checked for any relevant citations. A total of 11 studies involving 190,322 digital and 638,348 film mammography images were included. The cancer detection rates were significantly higher for digital mammography than for film mammography (risk relative, RR = 1.17; 95% confidence interval, CI = 1.06-1.29; I² = 19%). The advantage of digital mammography seemed greatest among patients between 50 and 60 years of age. There were no significant differences between the two methods regarding patient recall rates or the characteristics of the tumors detected. The cancer detection rates using digital mammography are slightly higher than the rates using film mammography. There are no significant differences in recall rates between film and digital mammography. The characteristics of the tumors are similar in patients undergoing the two methods.
Highlights
Breast cancer is the second most frequent malignant neoplasm among the female population.[1]
The objective of this systematic review of the scientific literature was to compare the performance of digital mammography and film mammography in terms of cancer detection rates, patient recall rates and characteristics of the tumors detected
We found one randomized controlled trial (RCT),[29] three paired studies[14,30,31] and seven cohort studies.[32,33,34,35,36,37,38]
Summary
Breast cancer is the second most frequent malignant neoplasm among the female population.[1]. The specific mortality rate is 11.4 per 100,000 women, which means that, each year, more than 10,000 women die from this disease.[2] There is evidence in the medical literature that suggests that periodic mammography screening is the most effective method for early diagnosis of breast cancer, with significant reductions in the specific mortality rates caused by this disease. One of the factors that most compromises film mammography is the fact that the images need to be developed and fixed chemically, and the image rejection rate due to processing errors can surpass 20%.8. Digital mammography does away with the chemical processing of images and, by enabling correction of brightness and contrast, can potentially reduce the rate of image rejection due to technical errors
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