Abstract
A study was conducted from December 2013 to March 2014 to compare the healing potential of decellularized porcine cornea (DPC) and small intestinal submucosa (DPSIS) for repairing of partial thickness corneal defect in rabbit model. Eighteen clinically healthy adult New Zealand White rabbits of either sex were divided into two groups. The porcine corneas and small intestinal submucosa were collected from abattoir and made acellular by treating with 1% sodium dodecyl sulphate. Under general anesthesia, a 5 mm diameter lamellar keratectomy wound was created over the peripheral cornea of rabbits under operating microscope in both the groups. The defect was repaired with DPC in Gr A and with DPSIS in Gr B. Corneal clarity was better in Gr A with less stromal scarring and incited less immune response than those of Gr B. Histopathological findings confirmed increased corneal neovascularization and fibroblast proliferation in Gr B than Gr A. On the basis of clinical, pathological and scanning electron microscopic examinations, DPC showed better corneal healing than DPSIS for repairing of corneal defect in rabbits.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
