Comparative Evaluation of Coronally Advanced Flap Procedure in Conjunction with Amniotic Membrane Versus Coronally Advanced Flap with Platelet-Rich Fibrin Membrane in Patients with Miller's Class I and II Gingival Recession Defects

Abstract

Abstract Introduction Amnion membrane (AM) and platelet-rich fibrin (PRF) have been used as Guided Tissue Regeneration (GTR)-based root coverage procedures in treatment of gingival recession. The objective of the present study was to comparatively evaluate the coronally advanced flap (CAF) procedure in conjunction with AM versus CAF with PRF in patients with Miller's class I and II gingival recession defects (GRD). Materials and Methods The sample size (Miller's Class I and Class II GRD) consisted of 24 patients who were stratified into two groups randomly (12 for each group). Group A patients were treated by CAF with PRF and Group B patients were treated by CAF with AM. Clinical parameters comprising plaque index (PI), gingival index (GI), pocket probing depth (PPD), clinical attachment level (CAL), and GRD were assessed at baseline, 3 months, and 6 months postoperatively. Results The percentage of root coverage obtained in the study groups was 62% and 77%, respectively, for Groups A and B. Statistically significant difference was obtained in the clinical parameters (PPD, CAL, and GRD) of Group B, which was treated by CAF with AM. Conclusion Significant difference was found between Group A (CAF+ PRF) and Group B (CAF+ AM) membrane treated sites in reduction of PPD, gain in clinical attachment level, reduction of GRD from baseline to 3 months and baseline to 6 months, with more significant results seen with Group B.