Abstract

The therapeutic activity of date palm extracts (Phoenix dactylifera) against paracetamol-induced hepatotoxicity was studied in rats of the Wistar strain. Forty-eight (48) Wistar rats were assigned into 8 groups equally. Group I (normal control) were given distilled water for 14 consecutive days. Group II (negative control) received paracetamol (2 g/kg). Group III were pretreated with aqueous extract (400 mg/kg) for 7 days before receiving paracetamol (2 g/kg) for 7 additional days. Group IV were pretreated with aqueous extract (400 mg/kg) for 7 consecutive days and paracetamol (2 g/kg) for 7 additional days. Group V– received 2 g/kg of paracetamol for 7days and given 400 mg/kg aqueous extract for additional 7 days. Group VI received paracetamol (2 g/kg) for 7days followed by ethanolic extract (400 mg/kg) for 7 additional days. Group VII were co-administered paracetamol (2 g/kg) and the aqueous extract (400mg/kg) for 7 days. Group VIII were co-administered paracetamol (2 g/kg) and ethanolic extract (400 mg/kg) for 7 days. To evaluate the efficacy of the extracts on paracetamol-compromised liver in Wistar rats, the enzyme activities of ALT, AST, ALP and bilirubin concentration in serum were investigated. Treatment with aqueous and ethanolic extracts at different timing significantly (p<0.05) decreased paracetamol-induced elevation of serum concentrations of ALT, AST and bilirubin. Concurrent administration of the extracts with paracetamol conferred better hepatoprotection compared to the prophylactic and curative treatments. The present findings suggest a potential therapeutic use of Phoenix dactyliferia in treatment of liver diseases.Keywords: Phoenix dactylifera, hepatoxicity, extract, paracetamol

Highlights

  • Liver disease is a global health challenge which falls into two broad categories: acute and chronic

  • Other plant-based products are being investigated for their hepatotherapeutic potential because nature is a rich source of innumerable amounts of phytochemicals that serve as potential precursors of novel therapeutic agents

  • The study was undertaken to evaluate the efficacy of date palm extracts administered using pre-treatment, co-administration and post-treatment methods on adult wistar rats with paracetamol-induced liver failure

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Summary

Introduction

Liver disease is a global health challenge which falls into two broad categories: acute and chronic. The authors chose date palm (Phoenix dactylifera) for the study based on its folkloric use. The study was undertaken to evaluate the efficacy of date palm extracts administered using pre-treatment, co-administration and post-treatment methods on adult wistar rats with paracetamol-induced liver failure.

Results
Conclusion

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