Comparative evaluation of amoxicillin plus metronidazole and doxycycline alone in the nonsurgical treatment of localized aggressive periodontitis

Abstract

Aim and Objective: To evaluate the effects of a combination of amoxicillin plus metronidazole and doxycycline alone in the nonsurgical treatment of localized aggressive periodontitis (LAP) and compare their effects on clinical and microbiological parameters during 90 days followup in patients with LAP. Materials and Methods: A total of 20 patients with LAP were included in the study. Collection of subgingival plaque samples and recordings of clinical parameters, that is, plaque index (PI), gingival index (GI), probing pocket depth (PPD), and clinical attachment loss (CAL) was done at baseline. The subjects were randomly divided into two groups. Group I subjects were given a combination of amoxicillin plus metronidazole and Group II subjects were given doxycycline. Full-mouth scaling and root planing (SRP) was performed at day 10. Collection of subgingival plaque samples and recording of clinical parameters was repeated at days 10, 30, and 90. Results: There was a statistically highly significant difference ( P P P Conclusion: Systemic administration of doxycycline with full mouth SRP resulted in a better improvement of periodontal parameters and elimination/suppression of putative periodontal pathogens such as Aa, Pg, and Tf, than amoxicillin plus metronidazole in patients with LAP.