Abstract
Background: Mandibular third molars (M3M) are the most common impacted teeth in the human dentition. Removal or extraction of these teeth is frightening for the patients owing to the perception of pain. As a result, pain control mechanism like anesthesia is the major factor that needs to be executed appropriately. Using newer local anesthetic drugs minimizes side effects and drug interactions. Levobupivacaine (Levo) is a congener of bupivacaine thereby minimizing the cardiotoxic effects of bupivacaine. Dexmedetomidine (Dex) is an alpha agonist which alongwith Levo is capable of providing prolonged duration of anesthesia decreasing the need for rescue analgesics.
 Aim: This study will compare the anesthetic effectiveness between Levo and Levo alongwith Dex during the extraction of impacted M3M.
 Methodology: A total of 50 consecutive systemically healthy patients requiring unilateral surgical extraction of impacted M3M with similar orientations will be divided into two groups randomly, one group (L) will receive nerve block with levo while the second group (LD) will receive Levo plus Dex during the extraction procedure.
 Results: ‘Students t-test’ will be used to analyse and evaluate. The patients will be evaluated based on different parameters. The patient will be asked to reciprocate about the first bout of pain experience based on the Visual Analog Scale that will be handed over to patient after the procedure. The other parameters that will be evaluated are Onset on Anesthesia, Depth of Anesthesia, Hemodynamics, Oxygen saturation level, Sedation level and duration of post-operative analgesia. The patient will be evaluated over the time duration after which the patient had to take a rescue analgesic.
 Conclusion: Levo with Dex is more efficient than Levo in providing prolonged duration of anesthesia and has prolonged duration of postoperative analgesia.
Highlights
Pain is experienced as an outcome of stimulation of receptors sensitive to a noxious stimulus
Levo interferes with the opening of the sodium channel, which inhibits conduction of the action potential and produces localised and reversible anesthesia
To compare the total number of analgesics consumed in two groups
Summary
Pain is experienced as an outcome of stimulation of receptors sensitive to a noxious stimulus. The duration of action is dosedependent and varies based on the anesthethic technique. It acts via blockade of voltagesensitive ion channels in neuronal membranes, preventing transmission of nerve impulses. Dexmedetomidine (Dex) is an alpha agonist which alongwith Levo is capable of providing prolonged duration of anesthesia decreasing the need for rescue analgesics. Aim: This study will compare the anesthetic effectiveness between Levo and Levo alongwith Dex during the extraction of impacted M3M. Methodology: A total of 50 consecutive systemically healthy patients requiring unilateral surgical extraction of impacted M3M with similar orientations will be divided into two groups randomly, one group (L) will receive nerve block with levo while the second group (LD) will receive Levo plus Dex during the extraction procedure
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