Comparative Efficacy of Vitamin D Supplementation and Zoledronic Acid Injection in Osteoporosis Treatment: A Clinical Study

Abstract

This study aimed to evaluate the efficacy of combined Vitamin D and zoledronic acid injection therapy in the treatment of osteoporosis. The control group received zoledronic acid injections through intravenous infusion. In contrast, the observation group was administered vitamin D drops in addition to the standard treatment. Comparative analysis revealed that the observation group demonstrated a significantly higher total effective rate than the control group. Post-treatment assessments indicated that levels of N-terminal propeptide of type I collagen and β-isomerized C-terminal telopeptide were substantially lower in the observation group as compared to the control group. The 25-hydroxyvitamin D levels in the observation group were notably higher. Post-treatment evaluations showed that the observation group had significantly higher bone mineral density in the femoral neck, hip joint, and L1–4 segments. The Oswestry Disability Index score was also found to be lower in the observation group post-treatment, indicating a reduction in disability. The incidence of adverse reactions was significantly lower in the observation group compared to the control group. In conclusion, the combination of Vitamin D and zoledronic acid injection demonstrates substantial effectiveness in treating osteoporosis by improving bone metabolic indices and bone mineral density while also enhancing the safety profile of the drug.