Abstract
Of 82 patients with an acute urinarytract infection (U.T.I.) treated with sulphadimidine, 63 % had a positive urine culture 48-72 hours after the start of therapy. This was due to the high prevalence of sulphonamide-resistant organisms. Of 60 patients treated with the combination of trimethoprim and sulphamethoxazole (co-trimoxazole), in only 2 was the 48-72 hour urine culture positive. In Ceylon, where the prevalence of sulphonamide-resistant urinary pathogens is high, sulphonamides can no longer be considered the drugs of choice in the treatment of acute urinary infections.
Published Version
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