Comparative Efficacy of Moxidectin Ivermectin Doramectin and Fenbandazole Against Natural Infection of Gastrointestinal Nematodes in Sheep at Hisar

Abstract

This study aim to evaluate the effectiveness of moxidectin (cydectin), ivermectin (Neomec), doramectin (dectomax) and fenbendazole (Panacur) against gastrointestinal nematodes in naturally infected sheep at central sheep breeding farm, Hisar, Haryana. The study includes 50 crossbred sheep divided randomly into five groups (group A, B, C, D and E) of 10 animal in each. Group A, B and C were treated with moxidectin, ivermectin, doramectin (@10 mg/kg BW) and group D with fenbendazole (@5 mg/kg BW) and group E served as the untreated control. The therapeutic efficacy was evaluated through determination of epg, body weight gain/loss and Hb concentration. Fecal, body weight and blood were collected before treatment on day 0, and on 7, 14 and 21 day post-treatment. The results showed that the fecal egg count reduction percentage in group A, B, C, D compared to control were 100, 90, 100 and 80 respectively on 21 day post treatment. The body weight of the treated group A, B, C sheep were slightly increased on 21 day post treatment but the differences was non-significantly (P<0.05) when compared with group D and E. The Hb values was significantly higher (p<0.01) between group A, B, C when compared with group D and E on day 21 post treatment. On the basis of these results it was concluded that moxidectin and doramectin proved the most effective against gastrointestinal nematodes of sheep in the present farm, while ivermectin being comparatively less and fenbendazole the least effective.