Abstract
The control of Newcastle Disease (ND) relies on the use of safe and effective vaccines. Live vaccines which are prepared with lentogenic strains of Newcastle Disease Virus (NDV) are now more frequently used in broilers and layers than vaccines prepared from chemically inactivated strains of NDV mixed with adjuvant. This is because live freeze-dried vaccines can be produced on a large scale at a relative low cost. The vaccines are easy to administer on large scale, and rapidly stimulate cell-mediated and mucosal surface immunity. The present study was designed to compare the efficacy of LaSota, B1 and Mukteswar Strain vaccines for NDV in layer chickens. Findings of our present study indicated that production of HI-antibody titre was higher in birds of group A (512) vaccinated with ND LaSota, compared to those of group B (256) vaccinated with RDV (Mukteswar strain); group C (128) vaccinated with ND B1 (B1 strain) Hitchner at six weeks after vaccination. Thus, the ND LaSota vaccine was found to be superior to some extent than ND B1 Hitchner. However, as regards vaccination of chicks against NDV in earlier days, the use of lentogenic strains are recommended although it should be kept in mind that vaccination with LaSota strains would cause greater problems in young susceptible birds than Hitchner B1 strain and even though LaSota induces stronger immune response Asian J. Med. Biol. Res. 2021, 7 (4), 332-338
Highlights
Newcastle disease (ND) is an acute contagious disease of pet, free living and domestic birds
The present study was conducted to compare the efficacy of following vaccination with ND-LaSota® (Lasota strain), RDV (Mukteswar strain), and Izovac B1 Hitchner® (B1 strain)
As regards to the principal objectives of the present study, it may be stated that production of hemagglutination inhibition (HI)-antibody was higher in birds of group A vaccinated with ND LaSota® compared to those of group B vaccinated with RDV (Mukteswar) and group C vaccinated with Izovac B1 Hitchner®
Summary
Newcastle disease (ND) is an acute contagious disease of pet, free living and domestic birds. The virus is distributed worldwide either as naturally circulating virus or as a vaccine virus. It has been constant in at least 241 species of birds representing 27 of 50 orders of the class Aves (Alexander, 1995b). ND is widely adaptable in type and severity of the disease it produces. It is complicated because various isolates and strains of the virus may induce variations in the severity of the disease even in a given host, such as, the chickens (Alexander, 1991).
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