Abstract
BackgroundOn account of deterioration of chronic heart failure (CHF) and extensive exploration of Chinese herbal injections (CHIs), we performed a network meta-analysis to investigate the efficacy of CHIs (Huangqi injection, Shenfu injection, Shengmai injection, Shenmai injection, Shenqi Fuzheng injection, Yiqifumai injection) on the basis of western medicine (WM) treatment in CHF.MethodsLiterature search was conducted in Embase, the Cochrane Library, Pubmed, Chinese Biological Medicine Database, China National Knowledge Infrastructure, Wanfang Database, Chinese Scientific Journal Database from inception to June 12nd 2017, and study selection was abided by a prior eligible criteria.ResultsUltimately, a total of 113 randomized controlled trials (RCTs) were enrolled. The clinical data of the effective clinical rate, left ventricular ejection fraction, cardiac output and others outcomes was estimated by Stata software and Winbugs software. Risk of bias was assessed by Cochrane Collaboration’s tools. Integrating the each outcome’s results, a combination of Shengmai injection/Shenmai injection and WM obtain a first rank in most outcomes, particularly primary outcomes.ConclusionsIn conclusion, on the basis of WM, Shengmai injection or Shenmai injection may be a perforable treatment in CHF. In terms of insufficient of this study, more high quality RCTs needed to implement to support our conclusions.
Highlights
On account of deterioration of chronic heart failure (CHF) and extensive exploration of Chinese herbal injections (CHIs), we performed a network meta-analysis to investigate the efficacy of CHIs (Huangqi injection, Shenfu injection, Shengmai injection, Shenmai injection, Shenqi Fuzheng injection, Yiqifumai injection) on the basis of western medicine (WM) treatment in Chronic heart failure (CHF)
Wang et al BMC Complementary and Alternative Medicine (2018) 18:41 commonly used in CHF treatment, all of them were authorized by China Food and Drug Administration (CFDA), namely Huangqi injection (HQI), Shenfu injection (SFI), Shengmai injection (SI), Shenmai injection (SMI), Shenqi Fuzheng injection (SQFZI), Yiqifumai injection (YQFMI), to explore and rank their efficacy in CHF by the approach of network meta-analysis (NMA)
Eligibility criteria and study selection A study was considered eligible if it suited for these criteria: 1) randomized controlled trial (RCT); 2) patients enrolled were diagnosed as CHF according to “Guidelines on the Diagnosis and Treatment of Heart Failure” conducted by The Chinese medical association cardiovascular epidemiology branch in 2014 [9] or “Clinical Guideline of New Drugs for Traditional Chinese Medicine” released by CFDA in 2002 [10]
Summary
On account of deterioration of chronic heart failure (CHF) and extensive exploration of Chinese herbal injections (CHIs), we performed a network meta-analysis to investigate the efficacy of CHIs (Huangqi injection, Shenfu injection, Shengmai injection, Shenmai injection, Shenqi Fuzheng injection, Yiqifumai injection) on the basis of western medicine (WM) treatment in CHF. Wang et al BMC Complementary and Alternative Medicine (2018) 18:41 commonly used in CHF treatment, all of them were authorized by China Food and Drug Administration (CFDA), namely Huangqi injection (HQI), Shenfu injection (SFI), Shengmai injection (SI), Shenmai injection (SMI), Shenqi Fuzheng injection (SQFZI), Yiqifumai injection (YQFMI), to explore and rank their efficacy in CHF by the approach of network meta-analysis (NMA). The goal of this study was to provide evidence-based hierarchies of the comparative efficacy and more insights for selection of CHF treatment
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