Abstract
The study was undertaken to evaluate the comparative efficacy of hydroalcoholic extracts of leaves of Tagetes erecta (T. erecta) and aerial parts of Centella asiatica (C. asiatica) on Excision, Incision and Dead space wound models in albino rats. Extract of T. erecta and C. asiatica (P T. erecta extract (250 and 500 mg/kg) showed significantly increased the wound breaking strength in incision wound model and wet and dry granulation tissue weights, breaking strength in a dead space wound model compare to control and C. asiatica treated group (P T. erecta extract showed potent wound healing activity then the reported C. asiatica in different wound parameters.
Highlights
Wound healing or wound repair, is the body’s natural process
The study was undertaken to evaluate the comparative efficacy of hydroalcoholic extracts of leaves of Tagetes erecta (T. erecta) and aerial parts of Centella asiatica (C. asiatica) on Excision, Incision and Dead space wound models in albino rats
The acute toxicity studies of the hydroalcoholic extract of leaves of T. erecta and aerial part of C. asiatica were found to be non-lethal up to dose of 2 g/kg body weight
Summary
Wound healing or wound repair, is the body’s natural process. Have regenerating dermal and epidermal tissues. The plant is widely distributed in Asia, Africa, and North and South America [2] This plant is reportedly useful in wound healing and protecting against ulcer formation and is reported to have antimicrobial properties. The extracts of C. asiatica plant are reported to have sedative, antidepressant, analgesic, and anticonvulsive effects [4] It is reputed within the Indian system of medicine for its use in treating chronic and obstinate eczema, psoriasis, syphilis and leprosy [5]. The titrated extract of C. asiatica contains three principal ingredients like asiaticoside, asiaticacid, and madecassic acid All these ingredients are known to be clinically effective in the treatment of systemic scleroderma, abnormal scar formation [6] and wound-healing activity [7, 8]. Parts of leaves of T. erecta and C. asiatica on different wound models
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