Abstract
Objectives: To compare the therapeutic efficacy and tolerability of two regimens of chlorpheniramine in combination with chloroquine in children with acute, symptomatic, uncomplicated falciparum malaria. A further aim was to examine the kinetics of the disposition of Plasmodium falciparum during treatment with these regimens. Chlorpheniramine reverses chloroquine resistance in Plasmodium falciparum in vitro and in vivo.
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