COMPARATIVE EFFICACY AND SAFETY OF STRIPPING OF MEMBRANES AND STRIPPING ON THE MEMBRANES PLUS SINGLE-DOSE VAGINAL MISOPROSTOL(25 mcg) ON THE OUTCOME OF LABOUR INDUCTION .

Abstract

Stripping of membranes is wide used as OPD procedure for pre-ripening and induction of labour. This study was planned to assess whether or not low single dose of vaginal misoprostol ( 25 mcg.) can be added to stripping in OPD and what is going to be the impact on the end result of labour induction. A total of eighty patients were taken for the study. They were divided in 2 equal Groups – Group S with only stripping of membranes and Group M Stripping along with 25 mcg Misoprostol. Primary observations were delivery at intervals forty eight hours from the beginning of induction and route of delivery. Secondary observations were interval from induction to onset of labour (latency period), interval from begin of induction to delivery (duration of labour), want for oxytocin augmentation, labour complications, Apgar scores at one and five minutes. Both groups were similar with respect to age, parity and between forty weeks and forty one weeks gestation. There was a considerably shorter latency period within the M group. The period of labour was considerably shorter in M group. Overall, baby outcomes were similar and comparable within the 2 groups. The study gave following results and conclusion – The patients who received Stripping with vaginal 25mcg Misoprostol(Group M) showed 1. A shorter latency period, 2. Less need for oxytocin augmentation, 3. Shorter duration of labour in patients. The two induction strategies were similar with respect to baby outcomes. Keywords: Cervical ripening; Induction; Labour; Misoprostol