Abstract
There is a lack of direct cross-comparison studies in clinical trials between immunotherapy alone and combination treatment, especially in Non-Small Cell Lung Cancer (NSCLC) patients with high PD-L1 expression. To determine if anti-PD-(L)1 antibody combined with chemotherapy is more efficient than immune checkpoint inhibitor (ICI) monotherapy for advanced NSCLC patients in the real-world data. We retrospectively collected 325 patients with advanced NSCLC treated with ICI alone with or without chemotherapy from 11th July 2016 to 26th May 2020 to investigate which treatment scenario is the most efficient, and how clinical factors impact response. Patients with advanced NSCLC were treated with ICI monotherapy (178/325, 54.8%) or in combination with chemotherapy (147/325, 45.2%). The objective response rate and disease control rate were higher in the combination group than the monotherapy group. Patients (including those with distant metastasis) treated with chemo-immunotherapy were associated with a significantly longer median PFS and OS compared with the monotherapy group, irrespective of the PD-L1 expression level and previous treatment lines. No significant increase in the risk of immune-related adverse events (irAEs) was found after combination with chemotherapy (50.6 vs. 57.8%). IrAEs predicted better PFS of immunotherapy in the monotherapy group, especially for patients with late irAEs (after ≥4 cycles). Collectively, we demonstrated that ICI monotherapy plus chemotherapy might have better anti-tumor activity and an acceptable side-effect profile regardless of PD-L1 level or previous treatment lines. Both regimens were well-tolerated and cost-effective, the more efficient is usually recommended.
Highlights
The advent of immune checkpoint inhibitors (ICIs) has radically changed the therapy paradigm in advanced Non-Small Cell Lung Cancer (NSCLC) over the past 5 years
The median Duration of response (DOR) was 18.9 months with combination group and 21.5 months with immunotherapy group; 50 (69.4%) of 72 patients in the combination group and 15 (48.4%) of 31 patients in the immunotherapy group had an ongoing response at the time of data cutoff (Table 2)
The analysis showed that the development of early immune-related adverse events (irAEs) was significantly associated with increased Progression-free survival (PFS) in immunotherapy arm [log-rank P = 0.053; multivariate hazard ratios (HRs), 0.621 (0.411–0.941), P = 0.024], which were consistent with previous studies [16, 17]
Summary
The advent of immune checkpoint inhibitors (ICIs) has radically changed the therapy paradigm in advanced NSCLC over the past 5 years. A remarkable improvement in the management of metastatic NSCLC occurred in 2015, when nivolumab was approved for the treatment of patients with progressive disease during or after a platinum-doublet treatment [1]. Both anti-programmed death 1 (PD-1) and anti- programmed death ligand-1 (PD-L1) antibodies have demonstrated their benefits in comparison with standard chemotherapy [2,3,4,5]. Deciding between therapeutics remains a challenge today The objective of this retrospective study is to investigate the efficacy and safety of ICI monotherapy or in combination with chemotherapy for advanced NSCLC patients in the real-world
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