Abstract
The purpose of this study was to compare bone regeneration and space maintaining ability of three-dimensional (3D) printed bone grafts with conventional biphasic calcium phosphate (BCP). After mixing polycaprolactone (PCL), poly (lactic-co-glycolic acid) (PLGA), and β-tricalcium phosphate (β-TCP) in a 4:4:2 ratio, PCL/PLGA/β-TCP particulate bone grafts were fabricated using 3D printing technology. Fabricated particulate bone grafts were mixed with atelocollagen to produce collagen-based PCL/PLGA/β-TCP composite block bone grafts. After formation of calvarial defects 8 mm in diameter, PCL/PLGA/β-TCP composite block bone grafts and BCP were implanted into bone defects of 32 rats. Although PCL/PLGA/β-TCP composite block bone grafts were not superior in bone regeneration ability compared to BCP, the results showed relatively similar performance. Furthermore, PCL/PLGA/β-TCP composite block bone grafts showed better ability to maintain bone defects and to support barrier membranes than BCP. Therefore, within the limitations of this study, PCL/PLGA/β-TCP composite block bone grafts could be considered as an alternative to synthetic bone grafts available for clinical use.
Highlights
A sufficient amount of residual bone in an edentulous alveolar ridge is required for successful implant treatment [1]
This study showed that the material had excellent mechanical strength and biocompatibility and that it was excellent in space maintenance ability and useful for new bone regeneration [5]
The purpose of this study was to develop block bone graft that was composed with collagen and PCL/PLGA/β-tricalcium phosphate (β-TCP) composite particles which were 3D-printed with SFF technique, and to evaluate space maintenance ability and new bone formation capability, comparing to biphasic calcium phosphate (BCP) which is widely used as calcium phosphate ceramics in dental practice
Summary
A sufficient amount of residual bone in an edentulous alveolar ridge is required for successful implant treatment [1]. The use of bone grafts has been popularized in bone defect reconstruction due to the development of tissue engineering and regenerative medicine [2]. Bone grafts are classified into autogenous bone grafts, allografts, xenografts, and synthetic bone grafts depending on donor tissues and materials [3]. To overcome the limitations of autogenous bone grafts, allograft and xenograft materials have been developed. Allografts and xenografts remain at risk for infection due to donor tissue [4,5,6]. A lot of interest has been focused on methods and materials for the production of synthetic bone grafts that can be produced on large scales and utilized without causing immune reactions [4,5,6,7]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
