Abstract
This study was conducted to evaluate the effects of a 3D-printed resorbable polycaprolactone/poly(lactic-co-glycolic acid)/β-tricalcium phosphate (PCL/PLGA/β-TCP) membrane on bone regeneration and osseointegration in areas surrounding implants and to compare results with those of a non-resorbable titanium mesh membrane. After preparation of PCL/PLGA/β-TCP membranes using extrusion-based 3D printing technology; mechanical tensile testing and in vitro cell proliferation testing were performed. Implant surgery and guided bone regeneration were performed randomly in three groups (a no membrane group, a titanium membrane group, and a PCL/PLGA/β-TCP membrane group (n = 8 per group)). Histological and histometric analyses were conducted to evaluate effects on bone regeneration and osseointegration. Using the results of mechanical testing; a PCL/PLGA/β-TCP ratio of 2:6:2 was selected. The new bone areas (%) in buccal defects around implants were highest in the PCL/PLGA/β-TCP group and significantly higher than in the control group (p < 0.05). Bone-to-implant contact ratios (%) were also significantly higher in the PCL/PLGA/β-TCP and titanium groups than in the control group (p < 0.05). When the guided bone regeneration procedure was performed using the PCL/PLGA/β-TCP membrane; new bone formation around the implant and osseointegration were not inferior to those of the non-resorbable pre-formed titanium mesh membrane.
Highlights
Dental implants for replacing missing teeth in partially or completely edentulous patients have been widely recognized in the last decade as a routine treatment modality that provides reliable long-term results [1,2,3]
The guided bone regeneration (GBR) principles introduced in 1959 by Hurley et al [8] involve the placement of a mechanical barrier membrane to contain blood clots and isolate bone defects from surrounding connective tissues, providing bone-forming cells with access to an enclosed space intended for bone regeneration [9,10]
The optical density of MG63 cells on PCL/poly(lactic-co-glycolic acid) (PLGA)/β-tricalcium phosphate (TCP) was similar to that on titanium from day 7, though they were significantly different (p < 0.001) until day 4 (Figure 9). These results suggest that the PLGA/PCL/β-TCP membrane could be used as a GPoBlyRmmerse2m01b5,r7a,npea.ge–page
Summary
Dental implants for replacing missing teeth in partially or completely edentulous patients have been widely recognized in the last decade as a routine treatment modality that provides reliable long-term results [1,2,3]. Of the variety of different barrier membrane materials [11] that have been used for successful GBR, extended polytetrafluoroethylene (e-PTFE) [12,13] and titanium mesh [14] are widely accepted in the clinical setting as non-resorbable membranes that induce minimal immunologic reactions and have excellent space-making ability They require a second surgery for membrane removal and have a high risk of premature membrane exposure [6,11]. Resorbable collagen [15] does not require a second surgery and shows excellent hemostasis, early wound stabilization, and provides chemotaxis for fibroblasts, but its limitations include unfavorable mechanical properties, lack of space-making ability due to rapid degradation, and early loss of barrier function [11,14] To overcome these limitations, studies on scaffold fabrication have been conducted using biodegradable synthetic polymers. Histological and histometric analyses were conducted to evaluate the effects of the 3D-printed resorbable PCL/PLGA/β-TCP membrane on bone regeneration ability and osseointegration in areas surrounding implants and results were compared with those of a non-resorbable titanium mesh membrane
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
