Abstract
The effects of theobromine and an extract of cocoa bean shell (CBS) on performance, serum constituent and physiological parameters were compared in rabbits. Synthetic theobromine (300mg/kg) and theobromine from CBS extract (3000mg/kg) were administered through oral gavage for 10 days. Synthetic theobromine and theobromine from CBS caused significant (p 0.05) effect on Na+, K+ and total protein. Synthetic theobromine induced significant (p Keywords : Synthetic theobromine, CBS extract, rabbits Global Journal of Pure and Applied Sciences Vol. 14 (3) 2008: pp. 253-256
Highlights
In recent times, there has been an increase in application of theobromine in chemotheraphy and theobromine at therapuetic dose of 500mg has been employed in the treatment of cardiac oodema and angina pectoric (Clark et al 1996)
Rossoff (2002), Mohammed et al (2000) have reported poor growth as the cause of theobromine from cocoa bean shell based diet fed to rat,.Odunsi and Longe (1995a) concluded that cocoa bean cake could only be included at low concentrations in chick starter and grower diets due to the presence of theobromine
The separated constituent of the extract were identified as theobromine and caffeine using Retension Factor (RF) as RF = Distance moved by spot Distance moved by solvent front which is 0.75 for theobromine and 0.94 for caffeine according to the method of Ciulei (1969)
Summary
There has been an increase in application of theobromine in chemotheraphy and theobromine at therapuetic dose of 500mg has been employed in the treatment of cardiac oodema and angina pectoric (Clark et al 1996). The levels of theobromine found in cocoa based meal are sufficiently high to cause metabolic disarrangement and subsequent toxicity in human and experimental animals (Wang et al 1992). Such toxic manifestation had been observed to include poor growth, low protein efficiency and nitrogen retention leading to death in rat (Wang and Waller, 1994). Theobroomine and diketopiperazine (Eteng and Ettarh 2000), theobromine, caffeine and theophylline (Ciulei, 1969), theobromine and caffeine (Adeyina 2007) It is not clear if the toxic manifestation observed in animals fed cocoa based meal is caused by theobromine or the synergistic effect of the constituent substance. This study is undertaken to observe the effect of theobromine extract of cocoa bean shell in comparison with the synthetic theobromine
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