Comparative Effects of Pamine, Banthine, and Placebos On Gastrointestinal Motility

Abstract

In a previous study (1) it was found that the effect of Banthine on gastrointestinal motility varied depending on whether the subjects were fasting or had received a meal following the administration of the drug. This observation, as well as our interest in keeping the d~g testing situation as nearly comparable as possible to the conditions under which these medications are administered clinically, prompted us to include the taking of a standard meal as part of a study of the effect of Pamine on gastric evacuation and the movement of the head of the column of barium along the intestine. Our subjects were eight adult males whose ages ranged from 22 to 50 years. They had been previously tested with a single dose of Pamine under fasting conditions and again when this drug had been administered four times daily in a therapeutic dose for three weeks prior to retesting (2). Data in this report consist of the results of the effect on motility of Pamine given by the oral route in a single dosage of 5 mg. and 10 mg. and, as control observations, the effects of Banthine 50 mg. and 100 mg. and of placebo tested under similar conditions. A total of 80 tests were performed.