Abstract
Dietary fatty acids have been implicated in the development of obesity and insulin resistance. This was a 36‐ week controlled, double masked randomized crossover study, to observe the effects of conjugated linoleic acid (CLA) and safflower oil (SAF) on markers of insulin sensitivity. Fifty‐five obese postmenopausal women with type 2 diabetes (T2DM) received 6.4 g mixed isomer CLA and 1.6 g SAF per day or 8.0 g SAF daily. Analyses of results at individual 5% level of significance were as follows. During diet period one (DP1), C peptide area under the curve was significantly higher while glycosylated hemoglobin and fasting glucose were significantly lower with SAF supplementation. There appeared to be no effect of CLA. Insulin sensitivity was improved in both diet periods by SAF as shown by a significant increase in quantitative insulin‐sensitivity index and significant decrease in HOMA assessment. In addition, SAF significantly reduced trunk adiposity and increased lean tissue as measured by DEXA. CLA had no significant effects on trunk adiposity. Dietary energy intake remained constant throughout the study. Reporting of adverse events did not differ between groups. In conclusion, CLA does not seem to affect insulin sensitivity, while SAF improves insulin sensitivity, which may be due to a reduction in visceral adiposity, in postmenopausal women with T2DM. Supported by Cognis GmbH.
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