Abstract
The hematological effects of cyclophosphamide have attracted considerable interest because they seem to differ from those of other nitrogen mustard derivatives and of total-body irradiation. This view is based partly on studies of patients with advanced malignant disease (1-3) and partly on studies in animals (4, 5). Extensive studies in rats have been made with the alkylating agents chlorambucil and busulfan; the effects of which were compared with the effect of total-body irradiation (6, 7). The present paper is part of a series of investigations designed to delineate more clearly, if possible, the differences in the hematological changes in rats after single doses of the nitrogen mustard derivative, cyclophosphamide, and total-body irradiation. The object of the experiments reported in this paper is to describe the differences in the biological effect in rats of total-body irradiation, cyclophosphamide, and nitrogen mustard (HN2) as expressed by survival, weight response, changes in number of circulating white blood cells, and alterations in bone marrow granulocyte
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