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Abstract
70% of the areas obtained when chloramphenicol was administered orally. Our experience confirms that of others 3. ' that the wide variation in chloramphenicol metabolism and excretion requires monitoring of serum concentrations periodically during therapy to ensure therapeutic concentrations and at the same time minimize the risk of dose-related toxicity. Dosage requirements may vary threefold in children of the same age. This variation is even greater in newborn and young infants, making monitoring of serum concentration even more imperative in this age group. We gratefully acknowledge the collaboration of Dr. Ronald Poland, Chief of Neonatology, Children's Hospital of Michigan, in collecting data on some of the infants in this study.
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