Abstract
The intestinal absorption of albendazole using surfactants (sodium taurocholate, sodium lauryl sulfate and mixed micelles) was studied. All experiments were performed on rat small intestine following intestinal perfusion. Solubilization of albendazole with sodium taurocholate improves the absorption constant of albendazole when compared to sodium lauryl sulfate induced solubilization (2.80 and 1.51 h −1, respectively). When mixed micelles (sodium taurocholate-oleic acid) were used the values for the absorption constant obtained (ranging from 1.056 to 1.135 h −1) showed a prevailing effect of oleic acid.
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