Abstract
We reported1 the protective action of sodium alum and tannic acid instillations against nasally instilled poliomyelitis virus in Rhesus monkeys. It was pointed out that the action of these chemicals was dependent on their concentration and was exerted on the nasal mu-cosa of the host rather than on the virus, although it appeared from one experiment that the potency of the test dose of virus influenced the results. Upon resuming this work at a later date we were unable to repeat our original results with sodium alum. Investigation of this failure disclosed the participation of the following factors: (1) the sodium alum which we used in the original experiments was assumed to have 24 molecules of water of hydration (as indicated by the manufacturers'label) while actually it possessed only 2 molecules and contained some insoluble A12O3; (2) the sodium alum used in subsequent experiments really had approximately 24 molecules of water of hydration, had no A12O3 and gave a clear solution, so that the actual am...
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