Abstract
Early studies of the relative effectiveness of different qualities of ionizing radiation, reviewed by Packard (1), were chiefly concerned with the effect of X-rays of therapeutic quality on small biological test objects. A more recent review by Zirkle (2) has summarized biological studies that have used a broad range of radiation qualities in an effort to correlate response to the energy transfer involved. Acute radiation death in mammals has not been widely employed as a criterion of relative effectiveness of X-rays in the therapeutic range. Potter (3) demonstrated a relationship between exit dose and lethality in rats with 100and 400-kvp X-rays wherein equal effect was noted when the exit doses were similar for compared qualities. A like relationship was observed by Ellinger et al. (4) for the exit dose and LDso in mice exposed to 140and 200-kvp X-rays. The implication that nonuniformity of depth dose can account for variation in effectiveness of X-rays has not been well established. Thus, the present study examines the relationship of acute lethality and depth-dose distribution in mice and rabbits exposed to X-rays ranging from 80 to 250 kvp.
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