Abstract
Background: There is a lack of study comprehensively comparing the effects of all existing types of interventions on global cognition among patients with mild cognitive impairment (MCI).Aims: To conduct a network meta-analysis to evaluate the effectiveness of different types of interventions in improving global cognition among MCI patients.Methods: Randomized controlled trials (RCTs) assessing the effects of pharmacological or non-pharmacological interventions on the Mini-Mental State Examination (MMSE) in MCI patients were included. Two authors independently screened the studies and extracted the data. Random-effects network meta-analysis was used to synthesize the data. Results were summarized as mean difference (MD) and corresponding 95% CIs of MMSE in forest plots.Results: Fifty RCTs with 5,944 MCI patients met the inclusion criteria and 49 were included in the network meta-analysis. Compared with the control group, cognition-based intervention (MD = 0.80, 95% CI 0.04–1.57), physical exercise (MD = 1.92, 95% CI 1.19–2.64), combined physical exercise and cognition-based intervention (MD = 1.86, 95% CI 0.60–3.12), and antioxidants (MD = 0.94, 95% CI 0.04–1.83) had positive effects on MMSE in participants with MCI. There was no significant difference between all other interventions included and the control group.Conclusions: This study suggested that cognition-based intervention, physical exercise, combined physical exercise and cognition-based intervention, and antioxidants could be among the most effective interventions on global cognition in older adults with MCI. The availability, acceptability, and cost-effectiveness of interventions should also be taken into consideration when selecting interventions.Registration: PROSPERO CRD42020171985.
Highlights
Mild cognitive impairment (MCI) is an intermediate state between physiological aging and somatic and psychological disorders such as Alzheimer’s disease and vascular dementia (Petersen et al, 2014)
Compared with the control group, cognition-based intervention (MD = 0.80, 95% CI 0.04–1.57), physical exercise (MD = 1.92, 95% CI 1.19–2.64), combined physical exercise and cognition-based intervention (MD = 1.86, 95% CI 0.60–3.12), and antioxidants (MD = 0.94, 95% CI 0.04–1.83) had positive effects on Mini-Mental State Examination (MMSE) in participants with MCI
This study suggested that cognition-based intervention, physical exercise, combined physical exercise and cognition-based intervention, and antioxidants could be among the most effective interventions on global cognition in older adults with MCI
Summary
Mild cognitive impairment (MCI) is an intermediate state between physiological aging and somatic and psychological disorders such as Alzheimer’s disease and vascular dementia (Petersen et al, 2014). Effective strategies to delay the process of cognitive decline in older adults have become a geriatric care priority (Song et al, 2018). Systematic reviews and meta-analyses have been conducted to measure the effect of different types of intervention on global cognition among MCI patients, including physical exercise (Song et al, 2018), cognition-based intervention (Wang et al, 2014), repetitive transcranial magnetic stimulation (Chou et al, 2020), acupuncture (Lan et al, 2020), western medication (Matsunaga et al, 2019), Chinese herbal medicine (Dong et al, 2016), probiotic (Den et al, 2020), vitamin, and mineral supplementation (McCleery et al, 2018). There is a lack of study comprehensively comparing the effects of all existing types of interventions on global cognition among patients with mild cognitive impairment (MCI)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
