Comparative Effectiveness of Cysteine, Lysine and Glycine to Fend Off Paracetamol-Induced Hepatic Insult

Ahmad M

doi:10.16966/2470-1009.112

Abstract

The aim of this study was to evaluate comparative effectiveness of cysteine, lysine and glycine to protect hepatocytes from toxic effects of paracetamol by monitoring liver function parameters in experimental rabbits. In this study design, animals were divided into two groups; Acute treated group and Chronic treated group. Each group was further divided into five sub-groups; Control Group (Group-I), Toxic group (Group-II), Cysteine treated group (Group-III), Lysine treated group (Group-IV) and Glycine treated group (Group-V). This study showed that cysteine, lysine and glycine markedly reduce the elevated liver enzymes in paracetamol induced hepatotoxic rabbits. In both acute and chronic toxicity study, there was a significant reduction in the level of liver indexes in cysteine and lysine treated group as compared to glycine treated animals. It is, therefore, concluded that cysteine and lysine have better clinical utilization as free redical scavengers as compared with glycine.

Highlights

Liver is an organ having both secretary and excretory functions
Toxic effects of paracetamol and protective effects of three amino acids including L-Cysteine, Lysine and Glycine were observed on SGOT, SGPT, ALP, LDH and total bilirubin levels (Table 1, Figure 1A)
In case ofchronic toxicity study, toxic effects of paracetamol and protective effects of three amino acids including L-Cysteine, Lysine and Glycine were observed on SGOT, SGPT, ALP, LDH and total bilirubin level (Table 2, Figure 1B)

Summary

Introduction

Liver is an organ having both secretary and excretory functions. Most of synthetic and metabolic functions of liver are performed by hepatocytes. Hepatocytes play important role in the metabolism and storage of proteins, carbohydrates, fats, vitamins and hormones. Plasma proteins are synthesized by liver parenchymal cells. Liver can both synthesize and remove cholesterol from body. Non-essential amino acids, when required, are synthesized by liver [1,2]

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