Abstract
Comparative Effect of Valsartan and Amlodipine on Insulin Resistance in Hypertensive Patients
Highlights
Hypertension is the most widespread cardiovascular disease
The patients participatedy in the study were randomized into two groups to receive the following treatments orally: Group I (Amlodipine no= 17): Amlodipine titrated from 5 mg to 10 mg daily, Group II (Valsartan no= 15): Valsartan titrated from 80 mg to 160 mg daily
The results showed that after 8 week treatment with amlodipine and valsartan, systolic blood pressure (SBP), diastolic blood pressure (DBP), fasting serum insulin (FSI) and homeostasis model assessment for insulin resistance (HOMA-IR) for both groups were significantly decreased in comparison with baseline data while fasting serum glucose (FSG) where non significantly decreased as shown in Table 2 and 3
Summary
Hypertension is the most widespread cardiovascular disease. Elevated arterial blood pressure damages blood vessels in kidney, heart, and brain and leads to an increased incidence of renal failure, coronary disease, heart failure and stroke. Pharmacologic treatment of blood pressure has been shown to prevent damage to blood vessels and to substantially reduce morbidity and mortality rates 1. Elevated blood pressure tends to impair glucose tolerance and induce a resistance to the actions of insulin rendering hypertensive patients at a risk of developing diabetes mellitus[3]. Non-treated patients with essential hypertension generally have higher fasting and postprandial insulin levels than normotensive patients. A direct relationship presents between blood pressure and fasting insulin levels in patients with essential hypertension 4
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